2010年版WHO肝和肝内胆管肿瘤的组织学分类

2010年版WHO肝和肝内胆管肿瘤的组织学分类

上皮性肿瘤：肝细胞性（Epithelial tumours: Hepatocellular）

良性Benign

肝细胞腺瘤(Hepatocellular adenoma )                                           

局灶性结节状增生(Focal nodular hyperplasia)

恶性相关或癌前病变Malignancy-associated and premanignant lesions

大细胞改变（曾称：异型增生）Large cell change(formarly “dysplasia”）

小细胞改变（曾称：异型增生）Small cell change(formarly “dysplasia”）

非典型增生结节(Dysplastic nodule)

低级別Low grade

高级别High grade 

恶性Malignant

肝细胞性肝癌hepatocellular carcinoma                                           

肝细胞性肝癌，纤维板层亚型Hepatocellular carcinoma, fibrolamellar variant    

肝母细胞瘤，上皮亚型Hepatoblastoma, epithelial variants                          

未分化癌Undifferentiated carcinoma

上皮性肿瘤：胆管性 Epithelial tumours: biliary

良性Benign

肝内胆管腺瘤（胆管周围腺错构瘤及其他）Bile duct adenoma (peribiliary gland hamartoma and others)                                                                          

微囊性腺瘤Microcystic adenoma                                                 

胆管腺纤维瘤Biliary adenofibroma                                             

癌前病变Premalignant lesions

胆管上皮内瘤变，3级（BilIN-3）Biliary intraepithelial neoplasia, grade 3 (BilIN-3)

导管内乳头状肿瘤伴低级别或中级别上皮内肿瘤Intraductal papillary neoplasm with low- or intermediate-grade intraepithelial neoplasia                                      

导管内乳头状肿瘤伴高级别上皮内肿瘤Intraductal papillary neoplasm with high-grade intraepithelial neoplasia                                                         

黏液囊性肿瘤伴低级别或中级别上皮内肿瘤Mucinous cystic neoplasm with low- or intermediate-grade intraepithelial neoplasia                                      

黏液囊性肿瘤伴高级别上皮内肿瘤Mucinous cystic neoplasm with high-grade intraepithelial neoplasia                                                                          

恶性Malignant

肝内胆管细胞癌Intrahepatic cholangiocarcinoma                                   

导管内乳头状肿瘤伴浸润性癌Intraductal papillary neoplasm with an associated invasive carcinoma                                                                          

黏液囊性肿瘤伴浸润性癌Mucinous cystic neoplasm with an associated invasive carcinoma

混合性或来源不定的恶性肿瘤 Malignancies of mixed or uncertain origin

钙化性巢状上皮-间质性肿瘤Calcifying nested epithelial stromal tumour                

癌肉瘤Carcinosarcoma                                                              

混合型肝细胞癌-胆管细胞癌Combined hepatocellular-cholangiocarcinoma          

肝母细胞瘤，上皮-间叶成分混合Hepatoblastoma, mixed epithelial-mesenchymal

恶性横纹肌样瘤Malignant rhabdoid tumour                                              

间叶肿瘤Mesenchymal tumours

良性Benign

血管肌脂肪瘤Angiomyolipoma (PEComa)                                           

海绵状血管瘤Cavernous haemangioma                                                

婴儿型血管瘤Infantile haemangioma                                         

炎性假瘤Inflammatory pseudotumour

淋巴管瘤Lymphangioma                                                              

淋巴管瘤病Lymphangiomatosis

间叶错构瘤Mesenchymal hamartoma

孤立性纤维性肿瘤Solitary fibrous tumour                                           

恶性Malignant

血管肉瘤Angiosarcoma                                                              

胚胎性肉瘤（未分化肉瘤）Embryonal sarcoma                                        

上皮样血管内皮瘤Epithelioid haemangioendothelioma                                 

Kaposi肉瘤Kaposi sarcoma                                                         

平滑肌肉瘤Leiomyosarcoma                                                          

横纹肌肉瘤Rhabdomyosarcoma                                                       

滑膜肉瘤Synovial sarcoma                                                          

生殖细胞肿瘤Germ cell tumours

畸胎瘤Teratoma                                                                  

卵黄囊瘤（内胚窦瘤）Yollk sac tumour (endodermal sinus tumour)                   

淋巴瘤Lymphomas

继发性肿瘤Secondary tumours