2020年版WHO食管肿瘤组织学分类
a. Benign epithelial tumors/precursors良性上皮肿瘤/前驱病变
i. Squamous cell papilloma
鳞状细胞乳头状瘤
ii. Esophageal squamous intraepithelial neoplasia (dysplasia), low-grade
食管鳞状上皮内瘤变（异型增生），低级别
iii. Esophageal squamous intraepithelial neoplasia (dysplasia), high-grade
食管鳞状上皮内瘤变（异型增生），高级别
iv. Esophageal glandular dysplasia (intraepithelial neoplasia), low-grade
食管腺异型增生（上皮内瘤变），低级别
v. Esophageal glandular dysplasia (intraepithelial neoplasia), high-grade
食管腺异型增生（上皮内瘤变），高级别
b. Malignant epithelial tumors恶性上皮肿瘤
i. Adenocarcinoma
腺癌
ii. Adenoid cystic carcinoma
腺样囊性癌
iii. Mucoepidermoid carcinoma
黏液表皮样癌
iv. Adenosquamous carcinoma
腺鳞癌
v. Squamous cell carcinoma鳞状细胞癌
1. Verrucous squamous cell carcinoma
疣状鳞状细胞癌
2. Spindle cell squamous carcinoma
梭形细胞鳞状细胞癌
3. Basaloid squamous cell carcinoma
基底样鳞状细胞癌
vi. Undifferentiated carcinoma
未分化癌
vii. Lymphoepithelioma like carcinoma
淋巴上皮瘤样癌
viii. Neuroendocrine tumor神经内分泌肿瘤
1. Neuroendocrine tumor, grade 1
神经内分泌肿瘤，G1级
2. Neuroendocrine tumor, grade 2
神经内分泌肿瘤，G2级
3. Neuroendocrine tumor, grade 3
神经内分泌肿瘤，G3级
ix. Neuroendocrine carcinoma神经内分泌癌
1. Large cell neuroendocrine carcinoma
大细胞神经内分泌癌
2. Small cell neuroendocrine carcinoma
小细胞神经内分泌癌
x. Mixed neuroendocrine–non–neuroendocrine neoplasm (MiNEN)混合性神经内分泌-非神经内分泌肿瘤
1. Combined small cell–adenocarcinoma
混合性小细胞癌-腺癌
2. Combined small cell–squamous cell carcinoma
混合性小细胞癌-鳞状细胞癌
