Prostate Acinar Adenocarcinoma,Foamy Gland Variant
夏成青 赵明 黄教悌
更新时间:2019-12-27 09:03:00
概述:
发病部位:前列腺
诊断要点:
3.多数病例细胞核小而深染,固缩呈圆形,无核增大或明显的核仁,仅部分(1/3)Gleason 7分或以上病例具明显核仁;
4.泡沫样型前列腺腺癌多数(60%)Gleason评分为7分,其次是Gleason评分6分(32%),8分(3%),9-10分(5%);
5.常在腺腔内见深嗜伊红的菱形结晶体,Gleason7分或以上的泡沫状腺体型前列腺腺癌(约33%)可见促结缔组织增生的间质反应;免疫组织化学染色:
分子标记:
鉴别诊断:
黄色瘤样肉芽肿:PSA、AMACR阴性,CD68阳性,且通常不伴经典的腺泡性腺癌结构。
预后:
治疗:
参考文献:
1. Joshua I, Warrick,Peter A, Humphrey.Foamy gland carcinoma of the prostate in needle biopsy: incidence, Gleason grade, and comparative α-methylacyl-CoA racemase vs. ERG expression.[J].The American journal of surgical pathology,2013,37(11):1709-14.
2. Zhao,J,Epstein,JI.High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases.[J].American Journal of Surgical Pathology,2009,33(4):583-590.